테트라사이클린(Tetracycline)을 함유한 지각과민처치제의 항균특성 및 세포독성 평가
Evaluation of the Antibacterial Effect and Cytotoxicity of Tetracycline Loaded Desensitizer
박지영, 배지명, 오승한, 최경희,
소속 상세정보
박지영 ( Park Ji-Young ) - 원광대학교 치과대학 치과생체재료학교실
배지명 ( Bae Ji-Myung ) - 원광대학교 치과대학 치과생체재료학교실
오승한 ( Oh Seung-Han ) - 원광대학교 치과대학 치과생체재료학교실
최경희 ( Choi Kyoung-Hee ) - 원광대학교 치과대학 구강미생물학교실
KMID : 0362220110380040313
Abstract
We prepared tetracycline loaded desensitizer by adding 0.1%, 0.5%, 1.0%,and 2.0% tetracycline to desensitizer (GLUMA, Heraus, Germany), and estimated the behavior of drug release, antibacterial effect, and cytotoxicity. The results of drug release test indicated that all of experimental groups showed the behavior of sustained and prolonged drug release. The released amount of tetracycline as a function of incubation time was proportional to the concentration of tetracycline loaded in desensitizer. The antibacterial test by using Streptococcus. aureus (SA. ATCC 6538, FDA 209) showed that the antibacterial effect of all experimental groups was significantly higher than that of control group (p<0.05). Cytotoxicity test by using agar diffusion assay indicated that control group (GLUMA) showed mild toxicity, and this cytotoxicity is supposed to be caused by one of desensitizer components showing weak antibacterial effect.
키워드
Antibacterial effect;Cytotoxicity;Desensitizer;Drug release;Tetracycline
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